Salivary Lipid Peroxidation and Lipid Profile Levels in Patients with Recent Ischemic Stroke

Abnormal lipid levels are an important risk factor in the development of atherosclerotic complications like stroke. Oxidative stress, lipid and lipoprotein Peroxidation are involved in neuronal damage induced by ischemia-reperfusion in stroke. Malondialdehyde (MDA) is widely utilized as a marker of lipid Peroxidation in state of elevated oxidative stress. The role of lipid in oxidative damage in saliva of patients with stroke is not yet completely elucidated. The aim of this study was evaluate the relationship of MDA as a marker of lipid Peroxidation with lipids and lipoprotein fractions and to find out the cut-off values of the studied parameters in saliva of patients with recent stroke . We studied 50 patients with ischemic stroke and other 25 ages and sex matched health control. To evaluate the oxidative status we measured the levels of Malondialdehyde in saliva and serum of all participants. Lipid profile was also estimated by the total cholesterol, triglycerides, LDL-C and HDL-C. MDA levels were significantly higher in patients with ischemic stroke than that of healthy control. Salivary critical value of triglycerides more than 0.5 mmol/L yields in highest accuracy rate (93%) to differentiate patients with ischemic from healthy control , followed by salivary MDA values which should be equal to or more than 0.38 μmol/L to be helpful in differentiation between two groups with (92% accuracy). Assessment of salivary lipid Peroxidation together with salivary lipid profile may be useful in early detection and monitoring of patients with increased risk of stroke. (J Int Dent Med Res 2010; 3: (2), pp. 57-64 )